Research into new ways of treating Chronic Lymphocytic Leukemia is going on all the time. As no current treatments for leukemia cure all the patients treated, doctors dealing with the disease are continually looking for new ways to treat it.

Project 4 - Immunology and Transplantation

John G. Gribben, D.Sc., F.R.C.P., F.R.C.Path., F.Med.Sci.
Barts and the London Cancer Center

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Recent advances in the use of donor lymphocyte infusion following allogeneic stem cell transplantation have illustrated that CLL cells is an excellent target of a graft versus leukemia (GVL) effect, although the target antigen may be minor histocompatibility antigens on CLL cells rather than true CLL specific tumor associated antigens. We aim to assess the nature of T-cell mediated and tumor immune responses following allergenic stem cell transplantation for CLL, and in particular, aim to assess whether there is evidence for a tumor specific graft versus leukemia effect in CLL.