Overview Slides/Movie
A brief set of slides that that introduces the CRC, the centeral mission and introduces each of the projects and core leaders. CLICK HERE to view the movie. Please note that there is NO audio to accompany the slides.
Project 1 - Molecular Genetics of CLL
Carlo M. Croce, M.D.
Ohio State University Cancer Center
Investigates the genetic basis for CLL.
Project 2 - Biochemistry of Apoptosis in CLL
John C. Reed, M.D., Ph.D.
The Burnham Institute
Investigates the leukemia-cell expression of genes and proteins important in the regulation of apoptosis (programmed cell death) and in defining leukemia cell resistance to pharmacologic or biologic therapy.
Thomas J. Kipps, M.D., Ph.D.
Moores UCSD Cancer Center
Januario E. Castro, M.D.
Moores UCSD Cancer Center
Danelle James, M.D.
Moores UCSD Cancer Center
Examines for leukemia-associated antigens and novel techniques for active immunotherapy, including gene therapy.
Project 4 - Immunology and Transplantation
John G. Gribben, D.Sc., F.R.C.P., F.R.C.Path., F.Med.Sci.
Bart's and the London Cancer Center
Examines the potential for adoptive immunotherapy with autologous or allogeneic leukemia-specific T- cells.
Project 5 - Novel Pharmacologic Agents in CLL
William Plunkett, Ph.D.
M.D. Anderson Cancer Center
Varsha Gandhi, Ph.D.
M.D. Anderson Cancer Center
Peng Huang, M.D., Ph.D.
M.D. Anderson Cancer Center
Examines compounds for Phase I/II testing and their mechanisms of action.
Michael R. Grever, M.D.
Ohio State University Cancer Center
John Byrd, M.D.
Ohio State University Cancer Center
Examines for treatment strategies that can achieve remission, and assesses the value of parameters that may serve as prognostic indicators.
Michael J. Keating, M.D., B.S.
M.D. Anderson Cancer Center
William G. Wierda M.D., Ph.D.
M.D. Anderson Cancer Center
Kanti R. Rai, M.D.
North Shore-Long Island Jewish Medical System
Jennifer R. Brown, M.D., Ph.D.
Dana-Farber Cancer Institute
Examines for treatment strategies that can achieve remission, and assesses the value of parameters that may serve as prognostic indicators.
Laura Rassenti, Ph.D.
Moores UCSD Cancer Center
Daniel L. Van Dyke, Ph.D.
Mayo Clinic
Nicholas Chiorazzi, M.D.
North Shore-Long Island Jewish Health System
Provides the necessary infrastructure for all the projects to achieve their potential and expedite their findings.
Donna S. Neuberg, Sc.D.
Dana-Farber Cancer Institute
Provides statistical support for the scientific projects and the cores in the Program Project.
Thomas J. Kipps, M.D., Ph.D.
Moores UCSD Cancer Center
Andrew W. Greaves
Moores UCSD Cancer Center
Mary Carpenter
Moores UCSD Cancer Center
Provides central programmatic leadership and coordination to improve and foster new relationships, to manage future planning, and to facilitate communication between investigators, projects, cores, and other consortium participants. In addition, is responsible for the collection, distribution, and security of clinical data management systems for the entire consortium.